The Greatest Cartoon of All Time
I'm a huge Calvin and Hobbes fan (like most reasonable people) but I wouldn't argue that it's the greatest overall comic strip of all time because I don't know how you choose something like that. Certainly, longevity and impact on the culture would have to give nods to Peanuts and Doonesbury, at the least. But this particular strip is my all-time favorite, and I stumbled upon it this morning purely by accident. I remember being in college when it came out and joking that this would be half of the fun of having kids, so you could essentially fuck with their heads.